FOXP3 is a transcription factor which is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most other cell surface markers (such as CD4 and CD25).
T regulatory cells, also known as suppressor T cells, are essential in the maintenance of immune homeostasis and self-tolerance. This subgroup of specialized T cells limits immune activation through a variety of direct and indirect interactions, many of which remain to be defined. Fully understanding Tregs will lead us to harnessing the capacity of these cells in order to develop stra...